Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012
Auteurs : Helena Grgi [Canada] ; Marcio Costa [Canada] ; Robert M. Friendship [Canada] ; Susy Carman [Canada] ; Éva Nagy [Canada] ; Zvonimir Poljak [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The objective of this study was to characterize H1N1 and H1N2 influenza A virus isolates detected during outbreaks of respiratory disease in pig herds in Ontario (Canada) in 2012. Six influenza viruses were included in analysis using full genome sequencing based on the 454 platform. In five H1N1 isolates, all eight segments were genetically related to 2009 pandemic virus (A(H1N1)pdm09). One H1N2 isolate had hemagglutinin (HA), polymerase A (PA) and non-structural (NS) genes closely related to A(H1N1)pdm09, and neuraminidase (NA), matrix (M), polymerase B1 (PB1), polymerase B2 (PB2), and nucleoprotein (NP) genes originating from a triple-reassortant H3N2 virus (tr H3N2). The HA gene of five Ontario H1 isolates exhibited high identity of 99% with the human A(H1N1)pdm09 [A/Mexico/InDRE4487/09] from Mexico, while one Ontario H1N1 isolate had only 96.9% identity with this Mexican virus. Each of the five Ontario H1N1 viruses had between one and four amino acid (aa) changes within five antigenic sites, while one Ontario H1N2 virus had two aa changes within two antigenic sites. Such aa changes in antigenic sites could have an effect on antibody recognition and ultimately have implications for immunization practices. According to aa sequence analysis of the M2 protein, Ontario H1N1 and H1N2 viruses can be expected to offer resistance to adamantane derivatives, but not to neuraminidase inhibitors.
Url:
DOI: 10.1371/journal.pone.0127840
PubMed: 26030614
PubMed Central: 4452332
Affiliations:
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first="Helena" last="Grgi">Helena Grgi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Marcio" sort="Costa, Marcio" uniqKey="Costa M" first="Marcio" last="Costa">Marcio Costa</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Friendship, Robert M" sort="Friendship, Robert M" uniqKey="Friendship R" first="Robert M." last="Friendship">Robert M. Friendship</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carman, Susy" sort="Carman, Susy" uniqKey="Carman S" first="Susy" last="Carman">Susy Carman</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Animal Health Laboratory, Laboratory Services Division, University of Guelph, Guelph, Ontario, N1H 6R8, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Animal Health Laboratory, Laboratory Services Division, University of Guelph, Guelph, Ontario, N1H 6R8</wicri:regionArea><wicri:noRegion>N1H 6R8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Nagy, Eva" sort="Nagy, Eva" uniqKey="Nagy E" first="Éva" last="Nagy">Éva Nagy</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Poljak, Zvonimir" sort="Poljak, Zvonimir" uniqKey="Poljak Z" first="Zvonimir" last="Poljak">Zvonimir Poljak</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The objective of this study was to characterize H1N1 and H1N2 influenza A virus isolates detected during outbreaks of respiratory disease in pig herds in Ontario (Canada) in 2012. Six influenza viruses were included in analysis using full genome sequencing based on the 454 platform. In five H1N1 isolates, all eight segments were genetically related to 2009 pandemic virus (A(H1N1)pdm09). One H1N2 isolate had hemagglutinin (HA), polymerase A (PA) and non-structural (NS) genes closely related to A(H1N1)pdm09, and neuraminidase (NA), matrix (M), polymerase B1 (PB1), polymerase B2 (PB2), and nucleoprotein (NP) genes originating from a triple-reassortant H3N2 virus (tr H3N2). The HA gene of five Ontario H1 isolates exhibited high identity of 99% with the human A(H1N1)pdm09 [A/Mexico/InDRE4487/09] from Mexico, while one Ontario H1N1 isolate had only 96.9% identity with this Mexican virus. Each of the five Ontario H1N1 viruses had between one and four amino acid (aa) changes within five antigenic sites, while one Ontario H1N2 virus had two aa changes within two antigenic sites. Such aa changes in antigenic sites could have an effect on antibody recognition and ultimately have implications for immunization practices. According to aa sequence analysis of the M2 protein, Ontario H1N1 and H1N2 viruses can be expected to offer resistance to adamantane derivatives, but not to neuraminidase inhibitors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Bourgeois, M" uniqKey="Bourgeois M">M Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rivailler, P" uniqKey="Rivailler P">P Rivailler</name></author><author><name sortKey="Conrardy, C" 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Boniotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kobayashi, M" uniqKey="Kobayashi M">M Kobayashi</name></author><author><name sortKey="Takayama, I" uniqKey="Takayama I">I Takayama</name></author><author><name sortKey="Kageyama, T" uniqKey="Kageyama T">T Kageyama</name></author><author><name sortKey="Tsukagoshi, H" uniqKey="Tsukagoshi H">H Tsukagoshi</name></author><author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M Saitoh</name></author><author><name sortKey="Ishioka, T" uniqKey="Ishioka T">T Ishioka</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Grgi, Helena" sort="Grgi, Helena" uniqKey="Grgi H" first="Helena" last="Grgi">Helena Grgi</name></noRegion><name sortKey="Carman, Susy" sort="Carman, Susy" uniqKey="Carman S" first="Susy" last="Carman">Susy Carman</name><name sortKey="Carman, Susy" sort="Carman, Susy" uniqKey="Carman S" first="Susy" last="Carman">Susy Carman</name><name sortKey="Costa, Marcio" sort="Costa, Marcio" uniqKey="Costa M" first="Marcio" last="Costa">Marcio Costa</name><name sortKey="Costa, Marcio" sort="Costa, Marcio" uniqKey="Costa M" first="Marcio" last="Costa">Marcio Costa</name><name sortKey="Friendship, Robert M" sort="Friendship, Robert M" uniqKey="Friendship R" first="Robert M." last="Friendship">Robert M. Friendship</name><name sortKey="Friendship, Robert M" sort="Friendship, Robert M" uniqKey="Friendship R" first="Robert M." last="Friendship">Robert M. Friendship</name><name sortKey="Grgi, Helena" sort="Grgi, Helena" uniqKey="Grgi H" first="Helena" last="Grgi">Helena Grgi</name><name sortKey="Nagy, Eva" sort="Nagy, Eva" uniqKey="Nagy E" first="Éva" last="Nagy">Éva Nagy</name><name sortKey="Nagy, Eva" sort="Nagy, Eva" uniqKey="Nagy E" first="Éva" last="Nagy">Éva Nagy</name><name sortKey="Poljak, Zvonimir" sort="Poljak, Zvonimir" uniqKey="Poljak Z" first="Zvonimir" last="Poljak">Zvonimir Poljak</name><name sortKey="Poljak, Zvonimir" sort="Poljak, Zvonimir" uniqKey="Poljak Z" first="Zvonimir" last="Poljak">Zvonimir Poljak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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